“Reimagining” Mice and Men

While everyone is preoccupied with mask-shaming and vaccine-cheerleading, scientists are engaged in critical research with a more lasting effect on our lives. For 100 years scientists have dreamed of creating and developing life outside of a womb. In March 2021 that dream came true. Scientists grew naturally conceived mouse embryos in tiny beakers for six days—the equivalent of the full first trimester of gestation. At this point the embryos had an identifiable body shape and organs. This miracle of modern science, posted in a YouTube video, garnered a mere 9,400 views.

In 2016, scientists developed the “right cocktail of growth factors and nourishment” and were able to incubate human embryos in a dish. The embryos attached to the dish “as if it were a uterus, sprouting a few placental cells.” The researchers halted the experiment due to the 4,000-member International Society for Stem Cell Research’s (ISSCR) 14-day rule. The ISSCR arrived at this limit based on the point in time at which the nervous system begins to develop.

Two separate research groups have now created their versions of synthetic embryos, called “human blastoids” from embryonic stem cells and “iblastoids” using reprogrammed adult skin stem cells. A real blastocyst is a human embryo around five or six days after fertilization that is growing. Normally, a blastocyst would implant in the wall of the uterus at around 7 or 8 days and the placenta would start to form. These advances prompted the ISSCR to rewrite its own yet to be revealed new guidelines allowing synthetic embryos to develop beyond the current 14-day limit.

As Dr. Frankensteinian as this sounds, researchers explain that the stem cell-produced embryos can be used to study congenital conditions, and the effects of drugs, toxins, and viruses on early development without using human embryos and perhaps create organs for transplants. Kind of like the good that would come from Dr. Fauci’s unethical “gain of function” research on coronaviruses (making them more deadly and transmissible). Look where that got us. 

We have truly entered the brave new world, grappling with the morality of life and death in the age of medical technology. Devaluing life is now commonplace. Abortion on demand is available on the day of birth. Freshly obtained aborted fetal tissue is being used to create “humanized mice” (on the taxpayers’ dime, no less). Not surprisingly, COVID-19 is the justification. Moreover, there is evidence that upstanding organizations and suppliers are making profits from the illegal sale of human fetuses.

In the United States, thousands of children are trafficked every year for sex or labor. This doesn’t make front page news or leave a lasting imprint on our consciousness—unlike the ever present COVID-19 statistics. 

On the other end of life’s spectrum, government COVID-19 policies regarding nursing home residents cemented what victims already knew: our society treats elders like jetsam—the debris that is thrown overboard to lighten a ship’s load. Former Obama advisor and member of Biden’s COVID-19 team, Ezekiel Emanuel, is on board. His “Complete Lives System” posits that medical care should be rationed based on one’s “instrumental value” to society. Babies, those over 60 years of age, and the disabled are out of luck. “When the worst-off can benefit only slightly while the better-off people could benefit greatly, allocating to the better-off is often justifiable.” One more nail in the coffin of our humanity. With doctors like this who needs the Grim Reaper. 

However, the unwanted cast-offs may be more difficult to replace with better models. Our reproductive abilities appear to be on the decline. The global fertility ratesperm counts, and the quality of sperm are declining and reported miscarriages increased at about 1 percent per year from 1970 to 2000.

Enter the robobabies. We could eliminate the need for mothers. We could ensure that only the right kind of embryos develop. Newspeak paves the way. The United Nations’ European Union and U.S. delegationshave neutered mother and father to “parents” and declared that “various forms of family exist.” 

Crazy? Social Justice Warriors are “reimagining” the evolution of our society. Why not reimagine humans?

Who would have imagined a pediatrician governor supporting infanticide? Who would have imagined that social media in America, the bastion of free speech, would crush politically unpopular speech and diversity of thought? Who would have imagined that physicians who offered early treatment of COVID-19 would be treated like drug dealers? Who would have imagined that the media-government complex would silence the reasoned opinions of renowned epidemiologists, virologists, and clinicians who raised questions about the response to COVID-19? Who would have imagined that 1984 would cease being fiction?

COVID-19 watchdogs have showcased their faux humanity, incessantly preaching that it is our moral duty to wear a mask and submit our bodies to an experimental drug. As science is catching up to longstanding utopian political agendas, our real moral duty is to reflect on playing God with life and death.

Playing Political Games Does Not Improve Patient Care

by Marilyn M. Singleton, MD, JD

Now that it is the political season where divisiveness rules the day, the bevy of President wannabes’ interest in maternal health is suspect. After all, none of them have joined the many maternal health advocates who praised the President for signing into law the Preventing Maternal Deaths Act which gives grants to the states to help identify the causes of maternal mortality.

According to the Centers for Disease Control and Prevention, black and American Indian/Alaska Native women are about 3 times as likely to die from a pregnancy-related cause as white women. These politicians are neither epidemiologists nor medical personnel yet they have diagnosed differences in maternal outcomes of black women as a product of racism. Their racial pandering serves to foment disharmony rather than initiate an honest examination of the problem.

Of course, those vying for political real estate will not preface their theories with some medical facts: uterine leiomyomas (fibroids), a cause of post-partum hemorrhage, are present in three times as many black women as white women. Or that the higher rates of high blood pressure in black Americans may be due to a gene that makes them more salt sensitive. Perhaps this contributes to the 50 percent higher incidence of hypertension of pregnancy (pre-eclampsia/eclampsia) in black women than in any other racial or ethnic group. White and Hispanic women have substantially the same rate of the disease and Asian and Pacific Island women have the lowest rate of any ethnic group. As a noted black female obstetrician patient safety and risk management expert called the cause of pre-eclampsia a “mystery” and noted, “older schools of thought attempted to use socioeconomic status as a reason to explain the problem, but it doesn’t hold up under statistical analysis.”

Do these politicians who label medical personnel as racists also tell you that 11 percent of obstetrician-gynecologists are black women (same as the general black population) and they were more likely than white or Asian ob-gyns to practice in federally funded underserved areas and areas with high poverty levels? Are these physicians racists?

Health problems are multifactorial and must be rigorously researched. While bias and social factors cannot be ignored, painting medical care personnel as racists will not advance the conversation.

Nor will depriving medical personnel of their religious rights eliminate discrimination in the delivery of medical care. Right of conscience laws have been on the books since the 1970s but the rules had been weakened and medical personnel began reporting workplace retaliation and harassment for their beliefs. Thus, the recently finalized Protecting Statutory Conscience Rights in Health Care rule ensures that medical personnel have the right to abstain from delivering certain medical services on the basis of religious beliefs or moral convictions.

The ink was barely dry on the final rule when San Francisco filed a lawsuit claiming it was “discriminatory.” The lawsuit alleges that the rule “prioritizes providers’ religious beliefs over the health and lives of women, lesbian, gay, bisexual, or transgender people, and other medically and socially vulnerable populations.”

First, as far as vulnerable populations, it appears black women have no trouble finding abortion providers: 49 percent of abortions are performed on white women and 40 percent on black women despite the fact that black women of childbearing age make up 14 percent of the population. Second, the lawsuit assumes that many physicians will wantonly begin to discriminate against LGBT patients. No one in the emergency room is asking the sexual history of a hemorrhaging patient.

Physicians who abide by the Oath of Hippocrates pledge to do no harm to their patients. Many physicians in their medical judgment do not believe that, for example, assisted suicide, sex-change surgery, and hormone blockers are harmless. Additionally, some surgeons simply have no desire to perform certain procedures just as breast cancer surgeons have no interest in bowel surgery.

The lawsuit contends that it is “the fundamental obligation of the medical profession and the right of patients to receive quality patient care.” The best care will come from physicians familiar and comfortable with the treatments sought. Certainly, in San Francisco with a major medical school and several large health systems, competent physicians who are well-versed in transgender surgery, sterilization, pregnancy termination, and euthanasia are available. The lawsuit is a political stunt.

No doubt some patients have experienced professionally unacceptable treatment. Fortunately, the universe filled with ethical professionals that this U.C. San Francisco-trained black female physician inhabits is more common than not. I have taken care of thousands of patients in public and private hospitals across the country. I’ve worked with hundreds of medical personnel, some of whom were not particularly warm and fuzzy with any of their patients. I cannot tell you what was in their hearts, but they always behaved professionally and competently.

Bio: Dr. Singleton is a board-certified anesthesiologist. She is President of the Association of American Physicians and Surgeons (AAPS). She graduated from Stanford and earned her MD at UCSF Medical School.  Dr. Singleton completed 2 years of Surgery residency at UCSF, then her Anesthesia residency at Harvard’s Beth Israel Hospital. While still working in the operating room, she attended UC Berkeley Law School, focusing on constitutional law and administrative law.  She interned at the National Health Law Project and practiced insurance and health law. She teaches classes in the recognition of elder abuse and constitutional law for non-lawyers.